Drugs that Cause Bone Marrow Depression

Unless otherwise noted, less than 3% of patients experienced this side effect when using the following drugs.

Accupril® (Parke-Davis) quinapril hydrochloride tablets
Accuretic™ (Parke-Davis) quinapril hcl/hydrochlorothiazide tablets
Adriamycin, USP, adriamycin
Aldoclor® (Merck) methyldopa-chlorothiazide
Aldoril® (Merck) methyldopa-hydrochlorothiazide
Altace® (King) ramipril
Azasan® (Salix) azathioprine tablets
Calcium disodium versenate (3M) edetate calcium disodium injection
Campath® (Berlex) alemtuzumab
Carbatrol® (Shire US) carbamazepine extended-release capsules
Cipro® (Bayer) ciprofloxacin
Clinoril® (Merck) sulindac
Cuprimine® (Merck) penicillamine
Doxil® (Tibotec) doxorubicin hcl liposome
Elspar® (Merck) asparaginase
Flexeril® (McNeil Consumer) cyclobenzaprine HCl
Floxin® (Ortho-McNeil) ofloxacin tablets
FML-S® (Allergan) fluorometholone and sulfacetamide sodium ophthalmic suspension
Indocin® (Merck) Indomethacin
Lotrel (Novartis)
Mavik® (Abbott) Trandolapril Tablets
Mefoxin® (Merck) Cefoxitin
Norpramin® (Aventis) desipramine hydrochloride
Primaxin® (Merck) Imipenem and Cilastatin
Prinivil® (Merck) Lisinopril
Prinzide® (Merck) Lisinopril-Hydrochlorothiazide
Sulfamylon® (Mylan) Brand of MAFENIDE ACETATE CREAM
Sulfamylon® (Mylan) Mafenide Acetate
Surmontil® (Odyssey) trimipramine maleate
Tegretol (Novartis)
Ticlid® (Roche Laboratories) ticlopidine hydrochloride
Topamax® (Ortho-McNeil) topiramate
Valcyte® *(Roche Laboratories) valganciclovir hydrochloride
Vaseretic (Merck)
Vasotec (Merck)
Vfend® (Pfizer) voriconazole
Vivactil® (Odyssey) Protriptyline HCl,

* Between 3% and 5% of Valcyte users have bone marrow depression.

Feedback, Comments, and Questions

Subj: Bone marrow depression?
Date: 5/8/2010
I would like to know if any cases of bone marrow depression have been reported with QUTIAPINE FUMERATE
Dr Nina

AskDocWeb: Bone pain is listed as one of the infrequent side effects but there are no reports of bone marrow depression.

Quetiapine fumarate (Seroquel XR) is an atypical antipsychotic used in the treatment of major depressive disorder (MDD), schizophrenia, bipolar disorder, and as adjunctive antidepressant therapy to other antidepressants.

Subj: Phenobarbitone Tablets
Date: 10/27/2010
I would like to know if any cases of bone marrow depression have been reported with Phenobarbitone Tablets I.P.(GARDENAL)
JAYANTHI

AskDocWeb: Phenobarbitone is a brand name of Phenobarbital (INN), a barbiturate first marketed as Luminal and Solfoton. It is the most widely used anticonvulsant worldwide and the oldest still commonly used. Drugs.com lists "weak bones" as one of the common side effects of this drug.

Subj: Nifedipine GITS (Gastrointestinal Therapeutic System)
Date: 11/7/2010
Can nifidipine gits cause bone marrow depression?
Rhoda

AskDocWeb: Bone marrow depression is very rare with Nifedipine. It occurs in less than 0.01% of patients, but it is possible.

Subj: Does Lisinopril cause bone marrow depression?
Date: 8/27/2011
I have been taking Lisinopril and Lisinopril-HCTZ. Has this drug been know to cause bone marrow depression?
Shirley

AskDocWeb: There are some cases of bone marrow depression with Lisinopril but these are vary rare. This effect has also manifested as hemolytic anemia, leukopenia/neutropenia and thrombocytopenia.

Subj: Arthrotec-decflenoc?
Date: 9/12/2011
arthrotec-decflenoc? I have taken arthrotec for 6 yrs and have been recently diagnosed with myelofibrosis. It is worthwhile to stop taking arthrotec.
Terry

AskDocWeb: That is something you would need to discuss with your physician. Myelofibrosis is a form of leukemia that affects bone marrow. It is most common in people over the age of 50. The condition gradually changes bone marrow tissue into scar tissue, which inhibits the bone marrow's ability to create new blood cells. Many people with Myelofibrosis get progressively worse yet it is possible to live symptom-free for years. We wish you well Terry, good luck.

Heart patient
Date: 2/28/2012
I want to know if a heart pt taking pyrimethamine 50mg daily along with aspirin, clopidogril, atorvastatin, lisinopril, in how much time he z likely to develop bone marrow suppression... nd which drug among all above is supposed to increase its toxicity???
Sadi

AskDocWeb: According to doublecheckmd.com Lisinopril may cause bone marrow damage/destruction (with abnormal production of blood cells) and aplastic anemia (rare failure of bone marrow). Statistics of these effects have not yet been quantified. Since bone marrow in large bones produce blood cells, the side effects to watch for include abnormal bruising or signs of bleeding such as bleeding from the gums, nose, digestive tract, vagina (females), dizziness, faintness, loss of consciousness, and/or rash, which are signs of problems with blood clot formation. If any of these develop, notify your physician immediately.

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This consumer advocate website is protected by copyright © 2002-2012 Askdocweb, Inc. All Rights Reserved. This is a layman's report on Procerin and is not intended to replace discussions with a health care provider. Do not use the information on this forum as a substitute for your doctor's advice. Always consult your doctor before taking any drug and follow your doctor's directions. Source material: Food and Drug Administration, Medline, Physician's Desk Reference, and the largest community of people in the world, those who are concerned about side effects and healthcare.