About Celebrex

If you’ve used Celebrex, please help others by sharing your experience with side effects. What would you tell your best friend about this product? Please remember that we do not give medical advice. That is for your local health care provider, who is familiar with your medical history. You can use the form below to add your comments, feedback or Celebrex review.

Subj: Coughing spasms
Date: 1/27/2011
The Celebrex was started by my internist for arthritic pain and what was later diagnosed by my orthopedist as mild osteochondritis in my knee joint. The knee has sustained a few injuries over the years, starting with a MVA at 20 years of age. The initial 100 mg dose was not helping enough, and after increasing this dose to 200 mg it has helped a great deal, but now I’m starting to notice coughing spasms, which also happed when I was on Vasotec. I’m guessing I may have to go back to 100 mg and have my internist prescribe some other pain medication. I’ve had gastric surgery, so NSAID meds must be limited.

Kathy

Subj: Dizzy
Date: 1/30/2011
I take 100mg of Celebrex in the morning with one 500mg of Vioxx three times a day and one Tylenol arthritis pill as precribed by my doctor..but most of the time I only take 2 Vioxx..I find when I add the Celebrex I get dizzy and when I get busy doing house work or just standing and cooking I get a terrible back ache I would like to stop the Celebrex but I cannot take any of the other insaids because they upset my stomach…I am going to ask my doctor if I took the Celebrex at night if it would help these side effects.

Miriam

AskDocWeb: It is surprising that there is any Vioxx left after the worldwide recall of that drug in September of 2004. Please talk to your doctor about the use of Voixx.

Subj: Overbearing side effects of Celebrex
Date: 2/6/2011
I have recently been diagnosed with a condition fibromalgia, and osteoarthritis in my fingers and toes. Was percribed 200mgs celebrex 1x a day. The drug did a great job taking the pain away however the side effects became overbearing for me. Big trouble with my hiatal-hernia, very unsettled upper and lower gi trouble, upset stomach and intestinal distress and gas. I also noticed that my face and fingers seemed to be retaining fluid. Another smyptom that started when on the drug was hot flashes and getting excessively warm like menopuase symptoms which I already went through over fifteen years ago. I was told by my physian’s office to come off the drug for a few days and see if symptoms improved. The swelling of face and fingers went away but my g.i. system is still not back to normal after being off the drug for five days! I was only on this drug for three weeks. I am upset that this drug has caused me so much distress because it really was a great relief for the joint pain.

Jane

Subj: Low red blood cells
Date: 2/6/2011
I am writing about celebrax. I have become very anemic for no reason that my doctors can find. I was given a paper about NSAIDs when I filled my last prescription for celebrax. It said one of the serious side effects of NSAIDs is low red blood cells. Do you know any thing about this?

Pat

AskDocWeb: Low red blood cells or low hemoglobin (anemia) is listed as a Serious Side effect of all Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). Celebrex may cause or worsen anemia. In controlled clinical trials the incidence of anemia was 0.6% with Celebrex and 0.4% with placebo. The manufacturer recommends that “Patients on long-term treatment with CELEBREX should have their hemoglobin or hematocrit checked if they exhibit any signs or symptoms of anemia or blood loss.” The symptoms of anemia vary depending on the cause but may include:

• Chest pain
• Cognitive problems
• Cold hands and feet
• Dizziness
• Fast or irregular heartbeat
• Fatigue
• Headache
• Pale skin
• Shortness of breath

If you experience unexplained fatigue make an appointment with your doctor.

Subj: Pins and needles numbness
Date: 2/10/2011
My friend is taking celebrex is it it possible that this is a side that she is having her left side of her head face & neck & shoulder has pins & needles & numbness

Gina

AskDocWeb: Although rare, it is possible. Severe tingling and numbness are listed as serious side effects that should be reported to the prescribing doctor. These symptoms can also have other causes that may be serious.

Subj: Celebrex and warfarin?
Date: 2/13/2011
celebrex and warfarin i have been on both celebrex for 3 months they cant get my blood to stay thin i am passing out nausea all the time flactuation and diarhea confusion have migraines and dry mouth have been seen by many experts noone knows an answer. i think it has to do with these two drugs. please help me

Angela

AskDocWeb: According to the FDA, patients who are taking warfarin concurrently with Celebrex have an increased risk of bleeding complications. It appears that this risk increases with age. Also, “It is important, however, that patients who are receiving warfarin and then start taking Celebrex (or who have any other change in the other medicines that they are taking) be monitored for changes in the level of their anticoagulation, with adjustments in the dose of warfarin if necessary.”

Subj: Psoriasis?
Date: 2/16/2011
I was prescribed celebrex for a shoulder injury .. it worked! The pain stopped almost immediately and I took the Celebrex for about a week. BUT … about 24 hrs after the first missed dose I developed a severe case of hives and the pain came back … I restarted the celebrex and the pain went away again. I stopped after a few days (and after reading alot of bad press about Celebrex) .. again the hives returned about a day later. I went straight to the doctor right as the hives were ‘peaking’ (they only lasted about an hour but were very severe covering my entire abdomen and arms). About a week later (and for the first time ever)I noticed plaque psoriasis lesions developing on both of my elbows and on my buttocks. I have been treating these for about a year and a half now and they seem to be getting worse – although very gradually. Is it possible the psoriasis was caused (or triggered) by the Celebrex?

Jon

AskDocWeb: So far the only drugs that are known to either worsen psoriasis or induce a flare-up are;

• Chloroquine
• ACE inhibitors such as monopril or captopril
• Beta blockers such as lopressor or atenolol
• Lithium
• Progesterone

Celebrex is actually prescribed for treating psoriatic arthritis in those who need more pain relief or cannot tolerate the side effects of NSAIDS.

One of the things that make psoriasis difficult to cope with is that it may be triggered by so many things; several kinds of emotional stress, prolonged stress, injury to the skin, certain types of infection, reaction to certain drugs, or a combination of these factors.

Different kinds of psoriasis have slightly different triggers. Pustular psoriasis may be triggered by internal medications, irritating topical agents, pregnancy, systemic steroids, infections, overexposure to UV light, emotional stress and sudden withdrawal of systemic medications or topical steroids, and exposure to certain chemicals.

Guttate psoriasis is most often triggered by bacterial infections, such as streptococcus ( strep throat )

Erythrodermic Psoriasis is the least common form of the disease. It can be triggered by severe sunburn, use of certain drugs, or abrupt withdrawal of oral steroids (cortisone), infection; and medications such as lithium, anti-malarial drugs, allergic reaction to a drug resulting in the Koebner response, and strong coal tar products.

Another trigger not to be overlooked in Psoriasis is the weather. Generally cold, dry weather will trigger psoriasis flare-up and the symptoms are in aggravated form during this time. During hot, sunny or damp weather the symptoms tend to decrease.

Subj: Long-term use of Celebrex
Date: 2/21/2011
I’ve used Celebrex for several years, and notice no significant side-effects. I don’t really know how much it helps, I assume it DOES help with my arthritis. Q: Does anyone know of any negative issues that come from long-term usage of it? Someone told me it’s not meant to be used indefinitely because of potential harmful effects on health. Thanks. Hope this helps.

Barry

AskDocWeb: There is some controversy about possible cardiovascular risks of using Celebrex long-term. The clinical trials have produced data that appears contradictory. One study, published in the British Medical Journal (2006), looked at the incidence of cardiovascular events in all previous randomized controlled trials of COX-2 inhibitors, as well as some trials of other NSAIDs. That study concluded that a significant increased cardiovascular risk did exist for celebrex. However, the increased risk in those using Celebrex was noted only at daily doses of 400 mg or greater.

Pfizer has agreed to fund a large, randomized trial that is specifically designed to establish more conclusively the cardiovascular risk profile of Celebrex. The trial, centered at the Cleveland Clinic, has a planned enrollment of 20,000 high-risk patients. Celebrex will be compared with the non-selective NSAIDS naproxen and ibuprofen. This trial is scheduled to be completed in 2013.

Several sources recommend that patients on long-term treatment with Celebrex should have a CBC, a chemistry profile and their hemoglobin or hematocrit checked periodically. Because serious GI tract ulcerations and bleeding can occur without warning symptoms, physicians should monitor for signs or symptoms of GI bleeding.

Subj: Trying to wean myself from Celebrex
Date: 2/23/2011
I have been taking 200 mg 1x Celebrex for 7 yrs. originally for RA but now for osteoarthritis. I am trying to wean myself from the drug but suffer severe headaches, pain and lethargy so seriously I was bedridden. This is not an easy drug with which to go cold turkey. I feel my high BP is a Celebrex factor.

Ruth

Subj: Gained a terrible amount of weight
Date: 3/15/2011
I went on here to see if you gain weight with Celebrex? I have gained a terrible amount of weight? Should get off of this and take something else. I guess it makes you gain weight.

Joni

AskDocWeb: The patient information for Celebrex says to check with your doctor as soon as possible if you experience unexplained weight gain.

Subj: Does Celebrex cause hair loss?
Date: 3/16/2011
does celebrex cause hair loss because i was looking at a bunch of reviews and comments that people who had taken celebrex submitted and a couple of people had complained that almost all of their hair had fallen out within two months. i just wanted to know because i will only be taking it for two weeks and i’m just 14 years old and i need my hair cause it’s still growing! I also wanted to know if you take celebrex for only two weeks, will you gain a significant amount of weight?

Pretoria

AskDocWeb: Only a small percentage of Celebrex users reported weight gain and hair loss, and most of those were from long-term use. If you are only taking it for a couple of weeks then you don’t have to worry about long-term side effects.

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