Feedback on Nexium Side Effects and Usage, page 42

Nexium Side Effects

If you’ve used Nexium, please help others by sharing your feedback. What would you tell your best friend about this product? Please remember that we do not give medical advice. That is for your local health care provider, who is familiar with your medical history.
Subj: Bone loss
Date: 6/8/2010
I’ve been taking Nexium for many years with little or no side effects. I worry about the possible bone loss issue (it stops the body from absorbing calcium and vit.D) So I tried to go off the product and started using OTC acid relievers including Prilosec(which gave me severe headaches). None of the stomach aids worked at reducing the amount of acid pumping into my stomach. I had to go back on Nexium … it’s the only thing that works, stop worrying about my bones and take vast amounts of calcium and Vit.D.


Subj: Neutropenia and lecupenia
Date: 6/9/2010
I have been on Nexium for 4 years. It is controlling my symptoms. However, I have recently developed mild neutropenia and lecupenia. All other blood indices are fine. Do you think it is related to Nexium? I would appreciate your help. I have provisionally stopped it.

Dr J

AskDocWeb: It may be possible, less than one percent (0.94%) of people taking Nexium report neutropeia. That combined with the reduced stomach acid that the body uses to kill bacteria could conceivably increase the chances of infection.

Neutropenia is a hematological disorder characterized by an abnormally low number of neutrophils, the most important type of white blood cell, in the blood. Neutrophils usually make up 50-70% of circulating white blood cells that serve as the primary defense against infections by destroying bacteria in the blood. Because of this, patients with neutropenia are more susceptible to bacterial infections and without prompt medical attention, the condition may become life threatening.

Subj: Anemia?
Date: 6/15/2010
I have been on Nexium for many years, and while it has worked well I have recently been diagnosed as being extremely anemic. Can this be a serious side effect from the nexium?


AskDocWeb: Yes, because Nexium reduces the production of stomach acid, it may interfere with the body’s ability to absorb iron salts resulting in anemia. This is listed among the hematologic side effects for Nexium, which included anemia, hypochromic anemia, cervical lymphadenopathy, epistaxis, leukocytosis, leukopenia, and thrombocytopenia. Pancytopenia and agranulocytosis have also been reported.

Subj: Diarrhea
Date: 6/16/2010
I have taken Nexium for over 5 years one hr. before breakfast and Sythoroid. At breakfast I take Mobic. The Nexium is to help me from having some problems with Mobic. I do have problems with diarrhea off and on. I have tried to get off Mobic but after a few days it is very difficult to walk.


Subj: Nexium side effects
Date: 6/18/2010
I have been a user of Nexium for many years, and yes it does work. However over the past couple years I have experienced a whole host of side effects. Chest pain, “two trips to the ER” no problems found. Being treated for depression, on going. Extremly high colestrol, being treated. Back pain, being treated daily with vicoden and regular trips to the chiropractor. Shortness of breath when doing anything remotly strenuous. Terrible gas and bowl irregularity. But the most debilitating of all ailments is the excessive tiredness. I even have gone to the extreme of doing a sleep study and now use a cpac machine to sleep at night, hoping it’s a sleep disorder causing my total tiredness. No such luck. My last hope is going to see a oncologist to do some indepth blood studies, to check iron levels in my bone marrow. My bones are weak as I found out about a year ago, I jumped down about four feet to the ground while hiking and shattered my left heal, calcium levels probabley arn’t what they should be. I just turned fifty years old, feel like I just turned seventy. After years of suffering various ailments that I never associated to the nexium, I really believe now after doing my research that the little purple pill is the culprit.


Subj: Laryngeal esophageal reflux
Date: 6/19/2010
I was recently diagnosed with Laryngeal esophageal reflux. The ONLY symptom that I have is a cough. I’ve taken Nexium for a week straight now…before that I had taken it for about 2 weeks with no relief of the cough. After this most recent week, I’m still coughing…should I continue taking it?? I really don’t feel like it’s doing any good for me. Thanks!


AskDocWeb: If you don’t feel like it’s doing any good then talk to your doctor. It is your responsibility to discuss your medical treatment options with your doctor. When talking about medication, find out if drugs other than the one your doctor first mentions are available. Ask about the advantages of one drug over another. You want to know why your doctor feels a certain drug is best for your condition. Ask what should you do if you forget to take a dose and how critical is taking the medication at the same time of day? If you start feeling better, can you stop the medication or is it important to continue the regimen or take it all? Do you need to avoid certain foods or alcohol while taking the medication? Your doctor is your healthcare consultant. Your job is to talk to them to find out what to expect from your illness and your treatment.

Subj: Continuous diarrhea
Date: 6/22/2010
One month ago I stopped Nexium due to insurance discontinuing coverage. My PCP has proscribed Prilosec as a replacement for my GERD but I haven’t received it from mail order yet. For the past month I have had continuous diarrhea and all tests have come back negative. I am seeing a GI at the end of the week. Could the stopping of Nexium cause the diarrhea?


AskDocWeb: The most common side effect of Nexium is diarrhea (4.3% of Nexium users) but that is while taking it. Remember that Nexium may mask or cover up the symptoms of another condition so seeing a GI is probably a good idea.

Subj: Body aches, chills, hoarseness, and depression
Date: 6/22/2010
In December I was diagnosed with H-Pylori and gastric lymphoma. After being treated with antibiotics and Omeprazole, both resolved. However, I continue to have chronic moderate to severe gastritis(according to my last gastroscope). A couple of weeks ago I was placed on Pantoprazole 40mg twice a day. Within a couple of days I was extremely fatigued, chills, hoarse, short of breath and my thought processes were dull. I was taken off the medication and had my heart checked–all fine.
After a week of doing nothing but sit in a chair, the doctor took me off the medication. Two and a half days later I began to feel back to normal, eating good and no stomach symptoms. Today the doctor placed me on 40mg of Nexium. Six hours after taking the first dose every bone and muscle in my body aches. I have chills, hoarseness and depression. Is there another class of medication that does not have the same ingredients as these two? I am a 62 years old, Caucasian female.


AskDocWeb: The class of medication for Nexium is PPI, or Proton Pump Inhibitor. Another class of GERD medications is called histamine receptor antagonists or H2 Blockers. Examples of this type of medication include:

  • Axid® (nizatidine)
  • Pepcid® (famotidine)
  • Tagamet® (cimetidine)
  • Zantac® (ranitidine)

Other medications such as prokinetic agents (Metoclopramide and Cisapride) and sucralafate are also available. Severe and/or complicated cases may require medications from multiple classes but your healthcare provider is the one to determine what class of medication is best for you.

Subj: Tumors?
Date: 6/25/2010
I have been on Nexium for about 8 yrs now and it has solved all my acid reflux problems, with no side affects at this time. I have heard feedback from some people that this drug can cause tumors, Is that true?

AskDocWeb: There was some concern about this possibility back in the 1990s but as more data became available it was found that the tumors only occurred in laboratory animals that received very high doses.

Subj: Difficulty breathing, chest pain and heaviness
Date: 6/26/2010
I have been recently diagnosed with GERD and have been using 40mg of Nexium, twice daily, since 06/01/2010. I also take 20 mg of Simvastatin and 20-25 mg of Lisinpril-HCTZ. At first, the Nexium help out a lot with the heavy chest, shext pain, acid in throat, dizziness, headaches and pain/pressure in neck and head. Recently, actually for the past four days, my symptoms have come back and will not go away. I have not been getting proper sleep because of them. But now, they stay with me in the daytime, too. I am scheduled for an endoscopy 07/19/2010; however, this issue with my GERD (before it was properly diagnosed 06/01/2010), has been going on since 04/22/2010, when I ate a Buffet Chinese restaurant. Before being properly diagnosed, I had been to the ER 7-10 times for panic attacks, total body tingling/numbness, difficulty breathing chest pain and heaviness, slurred speech (during panic attack), etc. (brought on by Dr. prescribing Paxil, Vistaril, Prozac..I do not take any of those now!!) I need to know if I need to see a GI or my Internal medicine doctor ASAP, because this has taken over my life. I no longer drive, work. Help, please!!!


AskDocWeb: When difficulty breathing is accompanied by chest pain, always get immediate medical attention. There is a moderately severe drug interaction listed between Simvastatin and Nexium. The concern is that co-administration with Nexium may increase the plasma concentrations of Simvastatin and the associated risk of myopathy, a condition or disease in which the muscle fibers do not function as they should. One patient reported experiencing symptoms of increased fatigue, mild chest pain, and shortness of breath that coincided with starting Nexium approximately six weeks prior to hospital admission. Theoretically, the interaction may also occur with other proton pump inhibitors like lansoprazole, omeprazole, and pantoprazole and HMG-CoA reductase inhibitors like Lovastatin and Simvastatin, since these drugs are all substrates of P-glycoprotein and CYP450 3A4. All patients treated with HMG-CoA reductase inhibitors are encouraged to report any unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever to their healthcare provider. Read more feedback about Nexium.
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